International review of 19 probiotic supplements containing De Simone Formulation (an 8-strain probiotic blend, previously known as VSL#3) found only 11 products passed all relevant criteria for IBS symptom management.

Last updated 4 October 2024 | Results reviewed by Daniel Keats RDN

1.1 Passed criteria

  • See table below for full results

This research project contains no affiliate links, sponsored products or ads.
Products are graded using transparent criteria and methodology.
Any commercially available product can be submitted for grading.
Results are published publicly without alteration.

 

View Methodology | Submit a Product

1.2 Table of results

Order of Results: Product names are listed alphabetically within each category.

Explanation of criteria

  1. Transparent Formula: The supplement’s ingredients and their amounts are openly labeled, not hidden behind proprietary blends. This transparency is essential for us to verify that it meets the studied dose requirements.
  2. Studied Dose: For De Simone in IBS populations, the effective dose is 900 billion CFUs per day in adults and 450 billion CFUs per day in children. Any product that delivers this specific dose in one or more servings meets this criterion.
  3. IBS RCT Probiotics Only: The product contains only probiotic strains that have been studied in IBS populations through randomized, placebo-controlled clinical trials. No other active ingredients are included, as unstudied additives may alter efficacy.
  4. Third-Party Tested CFUs: The manufacturer has submitted the product for third-party testing to verify both the CFU count (amount of probiotics in finished product) and has published the results on their website.
  5. Availability: Indicates where the product can be purchased. Please note that consumers worldwide can often access USA and UK products using a forwarding service.

1.3 Summary

  • We searched the entire web to find and evaluate products containing De Simone formulation.
  • 19 products were found containing De Simone.
  • 8 products failed as they could not be served at the studied dose – i.e. could not be expanded or divided to deliver the 900 billion CFU dose (for adults) that has been studied for **De Simone formulation.
  • This means that only 11 products met all our key criteria. Of these, no products published third-party testing results on their website.

Is a product missing?
Submit a product suggestion here.

Products are free to submit. We do not accept payment. Products are strictly graded using transparent and verifiable information.